By M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview

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Extra resources for Acetylcholine. An Approach to the Molecular Mechanism of Action

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This is in line with the fact that ACh itself, which contains a quaternary nitrogen, only penetrates the postsynaptic membrane with difficulty. These facts are important also to an understanding of the physiological action of the ChE inhibitors, and in particular of the irreversible organophosphorus inhibitors. For more than 20 years a careful comparison has been made of the physiological effect of anticholinesterases and the degree of inhibition of cholinesterase activity found in homogenates of tissues from poisoned animals.

The possibility may not, of course, be excluded that other synapses with these neurones are cholinergic, and that the action of ACh, applied electrophoretically, is on the ChR belonging to other synapses. The character of the response of these cells to the electrophoretic application of ACh differs, however, from that of the synaptic N-ChR of the Renshaw cells, is similar to that of the M-ChR reaction of the Renshaw cells, which are apparently non-synaptic, and is similar also to the reaction of the non-synaptic M-ChR neurones in vegetative ganglia (see Chapter 7).

CENTRAL ACTION OF TERTIARY AMINES AND QUATERNARY AMMONIUM COMPOUNDS INJECTED INTO MICE INTRAVENOUSLY AND INTRAVENTRICULARLY (Zeimal and Votava, 1961a, b; Zeimal and Satrapinsky, 1966) Substance Arecoline Nicotine Dimekamin Arpenal Atropine Benzacin Benactyzine Amedin VUFB 3100* Hexamethonium Thiameton Pentamin Dimelin Dicoline Metacin Benzacin ethiodide Benactyzine methiodide Benactyzine ethiodide Oxyphenonium C~*f*T\\vi\\ Jiption v w i u a i a^uvjii Subsi ances with tertiary nitrogen atom in molecule Tremor Convulsions Prevention of nicotine convulsions Prevention of nicotine convulsions Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor Substa nces with quaternary nitrogen atom in molecule Prevention of nicotine convulsions Prevention of nicotine convulsions Prevention of nicotine convulsions Prevention of nicotine convulsions Prevention of nicotine convulsions Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor Prevention of arecoline tremor * VUFB 3100 is the tertiary analogue of oxyphenonium.

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Acetylcholine. An Approach to the Molecular Mechanism of Action by M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview


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